Published online Jan 21, 2016. doi: 10.3748/wjg.v22.i3.1131
Peer-review started: May 12, 2015
First decision: August 25, 2015
Revised: September 24, 2015
Accepted: November 24, 2015
Article in press: November 24, 2015
Published online: January 21, 2016
Core tip: This is a review of the recent literature that analyze the impact of prognostic factors in patients affected by gastric cancer (GC). The results from the principal clinical trials regarding treatment for GC patients are controversial. Adjuvant therapy for locally advanced disease remains undefined in different countries. Prognostic factors can help clinicians to select those patients who can benefit more from combined post-operative therapy with radiochemotherapy and should be considered in the multidisciplinary meetings.