Retrospective Study
Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 7, 2016; 22(17): 4380-4388
Published online May 7, 2016. doi: 10.3748/wjg.v22.i17.4380
Clinicopathological features of familial adenomatous polyposis in Korean patients
Sung Min Jung, Yong Sik Yoon, Seok-Byeong Lim, Chang Sik Yu, Jin Cheon Kim
Sung Min Jung, Yong Sik Yoon, Seok-Byeong Lim, Chang Sik Yu, Jin Cheon Kim, Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Seoul 05505, South Korea
Sung Min Jung, Yong Sik Yoon, Seok-Byeong Lim, Chang Sik Yu, Jin Cheon Kim, Asan Medical Center, Seoul 05505, South Korea
Author contributions: Jung SM designed and wrote manuscript; Kim JC designed study and provided critical comments on manuscript; Yoon YS, Lim SB and Yu CS provided clinical data and were also involved in editing the manuscript; all authors have read and approved the final version to be published.
Supported by Korea Research Foundation, Ministry of Science, ICT, No. 2013R1A2A1A03070986 (to Kim JC); Future Planning, the Korea Health 21 R&D Project, No. HI06C0868 and No. HI13C1750; and the Center for Development and Commercialization of Anti-Cancer Therapeutics, Ministry of Health and Welfare, South Korea, No. HI10C2014.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Asan Medical Center (No. 2015-0585).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jin Cheon Kim, MD, PhD, Professor, Division of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, 88 Olympic-ro 43 gil, Songpa-gu, Seoul 05505, South Korea. jckim@amc.seoul.kr
Telephone: +82-2-30103489 Fax: +82-2-4749027
Received: December 6, 2015
Peer-review started: December 7, 2015
First decision: January 28, 2016
Revised: February 2, 2016
Accepted: March 2, 2016
Article in press: March 2, 2016
Published online: May 7, 2016
Core Tip

Core tip: Diagnostic delay to make adequate management harder, resulting in advanced colorectal cancer and accompanying morbidities, was not uncommon in patients with familial adenomatous polyposis. This study investigated prognostic factors and the correlation between APC mutations and clinical features, including extracolic manifestations. The present study revealed that early diagnosis and management of high-risk patients is essential and suggests the necessary APC mutations testing in the diagnosis and counseling of patients by informing on disease prognosis.