Copyright
©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 21, 2016; 22(11): 3289-3295
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3289
Published online Mar 21, 2016. doi: 10.3748/wjg.v22.i11.3289
Delayed diagnosis of alpha-1-antitrypsin deficiency following post-hepatectomy liver failure: A case report
Benjamin Norton, Peninsula College of Medicine and Dentistry, Tamar Science Park, Plymouth PL6 8BU, United Kingdom
Jemimah Denson, Department of Histopathology, Plymouth Hospitals NHS Trust, Plymouth PL6 8DH, United Kingdom
Christopher Briggs, Matthew Bowles, David Stell, Somaiah Aroori, Peninsula HPB Unit, Derriford Hospital, Plymouth PL6 8DH, United Kingdom
Author contributions: Norton B and Aroori S wrote the paper; Denson J, Briggs C, Bowles M, Stell D and Aroori S were the doctors involved in the case, and advised with regard to the research; Aroori S provided the CT images and Denson J provided the histology images; all authors have read and approved the final manuscript.
Institutional review board statement: This case report was exempt from the Institutional Review Board standards at Peninsula School of Medicine and Dentistry.
Informed consent statement: The patient’s relative involved in this study gave there verbal informed consent authorising use and disclosure of there protected health information.
Conflict-of-interest statement: All the authors have no conflicts of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Somaiah Aroori, MS, MD, FRCS, EBS in HPB Surgery, Consultant HPB Surgeon, Peninsula HPB unit, Derriford Hospital, PL6 8DH Plymouth, United Kingdom. s.aroori@nhs.net
Telephone: +44-7837388342
Received: May 24, 2015
Peer-review started: May 25, 2015
First decision: July 19, 2015
Revised: September 5, 2015
Accepted: November 30, 2015
Article in press: December 1, 2015
Published online: March 21, 2016
Peer-review started: May 25, 2015
First decision: July 19, 2015
Revised: September 5, 2015
Accepted: November 30, 2015
Article in press: December 1, 2015
Published online: March 21, 2016
Core Tip
Core tip: A report of a 60-year-old male who underwent an extended right hepatectomy for metastatic colorectal adenocarcinoma. He subsequently developed post-hepatectomy liver failure secondary to a delayed diagnosis of alpha-1-antitrypsin deficiency. Clinicians should be aware of, and test for, the possibility of undiagnosed alpha-1-antitrypsin deficiency in patients with known chronic obstructive pulmonary disease or a family history, undergoing major liver resection.