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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 14, 2015; 21(6): 1838-1844
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1838
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1838
Fibroblast growth factor receptor 4 protein expression and clinicopathological features in gastric cancer
Hao Chen, Dan-Ping Shen, Zi-Zhen Zhang, Jia-Hua Liu, Xing-Zhi Ni, Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Yan-Ying Shen, Department of Pathology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Author contributions: Chen H, Shen YY and Ni XZ designed the study; Shen DP and Liu JH analyzed the data; Chen H wrote the paper; Ni XZ and Zhang ZZ revised the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Xing-Zhi Ni, MD, Professor of Medicine, Department of General Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Shanghai 200127, China. niyin92@gmail.com
Telephone: +86-21-68383731 Fax: +86-21-58394262
Received: April 17, 2014
Peer-review started: April 18, 2014
First decision: May 29, 2014
Revised: August 4, 2014
Accepted: September 5, 2014
Article in press: September 5, 2014
Published online: February 14, 2015
Peer-review started: April 18, 2014
First decision: May 29, 2014
Revised: August 4, 2014
Accepted: September 5, 2014
Article in press: September 5, 2014
Published online: February 14, 2015
Core Tip
Core tip: This study investigated the possible contributions of fibroblast growth factor receptor 4 (FGFR4) protein expression as a risk factor for gastric cancer (GC), and the associations between protein expression and clinicopathological parameters. The results suggested that FGFR4 protein expression may correlate with the expression of Topo IIα. Furthermore, we demonstrated that FGFR4 protein expression is not a risk factor for GC initiation, but may be a useful prognostic marker for GC patients with tumors which are relatively small, well differentiated, or in the early stages of invasion.