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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 7, 2015; 21(5): 1498-1509
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1498
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1498
S-phase arrest after vincristine treatment may promote hepatitis B virus replication
Lei Xu, Zeng Tu, Ge Xu, Jie-Li Hu, Xue-Fei Cai, Yu-Wei Wang, Yuan Huang, Juan Chen, Ai-Long Huang, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing 400016, China
Lei Xu, Zeng Tu, Department of Microbiology, Chongqing Medical University, Chongqing 400016, China
Xing-Xing Zhan, Department of Pediatrics, Chongqing Medical University, Chongqing 400016, China
Author contributions: Xu L performed the majority of the experiments; Tu Z, Xu G, Hu JL and Cai XF made substantial contributions in conceiving and designing the study; Zhan XX, Wang YW and Huang Y contributed to the analysis and interpretation of the data; Chen J and Huang AL designed the study; Huang AL provided financial support for this work.
Supported by National Natural Science Foundation of China, No. 81201282 and No. 30901280; Grants from Chongqing Natural Science Foundation, No. cstc2012jjA10047; and the PhD Programs Foundation of the Ministry of Education of China, No. 20125503120004.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ai-Long Huang, Professor, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China. ahuang@cqu.edu.cn
Telephone: +86-23-68486780 Fax: +86-23-68486780
Received: May 7, 2014
Peer-review started: May 8, 2014
First decision: June 27, 2014
Revised: July 4, 2014
Accepted: September 19, 2014
Article in press: September 19, 2014
Published online: February 7, 2015
Peer-review started: May 8, 2014
First decision: June 27, 2014
Revised: July 4, 2014
Accepted: September 19, 2014
Article in press: September 19, 2014
Published online: February 7, 2015
Core Tip
Core tip: Hepatitis B virus (HBV) reactivation is an emerging clinical challenge for HBV carriers receiving anti-cancer chemotherapy. However, the mechanism for the sharp increase in viral replication in the early stages of chemotherapy is still unclear. In this research, we found that vincristine, which is a cytotoxic drug, had a direct stimulatory effect on HBV replication without the involvement of immune factors and that vincristine induced cell cycle arrest; cell proliferation inhibition may be conducive to viral replication, and this may be a novel mechanism of HBV reactivation following cytotoxic chemotherapy.