Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells
Yan-Chang Lei, Department of Infectious Diseases, Zhejiang Hospital, Hangzhou 310013, Zhejiang Province, China
Yan-Chang Lei, Ling-Ling Yang, Wen Li, Pan Luo, Infectious Disease Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China
Pei-Fen Zheng, Department of Gastroenterology, Zhejiang Hospital, Hangzhou 310013, Zhejiang Province, China
Author contributions: Lei YC designed the research; Lei YC, Yang LL, Li W, Luo P, and Zheng PF performed the research and analyzed the data; Lei YC and Zheng PF wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81160065.
Institutional review board statement: The study was reviewed and approved by Zhejiang hospital Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Zhejiang Hospital (IACUC protocol number: 126).
Conflict-of-interest statement: We declare that there are no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Pei-Fen Zheng, Chief Physician, Department of Gastroenterology, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, Zhejiang Province, China. ycleihust@sina.com
Telephone: +86-571-81595081 Fax: +86-571-87980175
Received: May 24, 2015
Peer-review started: May 29, 2015
First decision: June 25, 2015
Revised: August 9, 2015
Accepted: October 12, 2015
Article in press: October 13, 2015
Published online: December 14, 2015