Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11854
Peer-review started: February 10, 2015
First decision: April 23, 2015
Revised: June 9, 2015
Accepted: August 31, 2015
Article in press: August 31, 2015
Published online: November 7, 2015
Core tip: The murine models of colon cancer represent an important tool for understanding the etiopathogenesis and evaluating management strategies for colorectal cancer, thus representing a resource of immense potential in cancer research. Over the years, the increased understanding of the murine models of human colon cancer have resulted in the development of various models. We evaluated the current literature for various reported orthotopic colon cancer models. Our paper discusses the techniques, results, advantages and limitations of the presently available murine models of colorectal cancer so that a researcher can choose an appropriate colorectal cancer murine model which fits their research goals.