Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11709
Peer-review started: June 1, 2015
First decision: June 23, 2015
Revised: July 28, 2015
Accepted: September 30, 2015
Article in press: September 30, 2015
Published online: November 7, 2015
Core tip: For many decades the predominant view of molecular functioning of organisms stated that proteins represent the main regulators of genomes and their dysfunctions were the first cause of diseases. This protein-centred view was too simplistic to explain the complexity of cancer. In the last few years many studies have revealed that about 85% of our genome is pervasively transcribed, mainly as non-protein-coding RNAs (ncRNAs). The discovery of countless molecular alterations of ncRNAs related to cancer changed the paradigms of cancer biology. In this review, we report recent advances in the discovery of ncRNAs involved in Colorectal Cancer pathobiologies, and their potential applications in diagnosis, prognosis and therapy.