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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Nov 7, 2015; 21(41): 11680-11687
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11680
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11680
Competing endogenous RNA networks and gastric cancer
Lei-Lei Guo, Section of Infection Control of the Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou 450007, Henan Province, China
Chun-Hua Song, Peng Wang, Li-Ping Dai, Jian-Ying Zhang, Kai-Juan Wang, Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan Province, China
Chun-Hua Song, Peng Wang, Li-Ping Dai, Jian-Ying Zhang, Kai-Juan Wang, Henan Key Laboratory of Tumor Epidemiology, Zhengzhou 450001, Henan Province, China
Author contributions: Guo LL drafted the manuscript; Song CH, Wang P, Dai LP, Zhang JY and Wang KJ provided substantial contributions to conception of the manuscript, and helped draft the article or make critical revisions related to important intellectual content of the manuscript.
Supported by National Nature Science Foundation of China, No. 81373097.
Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kai-Juan Wang, PhD, Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, No. 100 Science Avenue, Zhengzhou 450001, Henan Province, China. kjwang@163.com
Telephone: +86-371-67781454
Received: April 28, 2015
Peer-review started: May 4, 2015
First decision: July 14, 2015
Revised: August 12, 2015
Accepted: September 15, 2015
Article in press: September 15, 2015
Published online: November 7, 2015
Peer-review started: May 4, 2015
First decision: July 14, 2015
Revised: August 12, 2015
Accepted: September 15, 2015
Article in press: September 15, 2015
Published online: November 7, 2015
Core Tip
Core tip: Competitive endogenous RNAs (ceRNAs) share microRNA (miRNA) response elements and compete common miRNAs, thereby regulating each other’s expression. The ceRNA regulatory networks including mRNAs, miRNAs, long non-coding RNAs and circular RNAs play critical roles in tumorigenesis, and the perturbations of ceRNA networks may contribute to the pathogenesis of gastric cancer.