Published online Sep 28, 2015. doi: 10.3748/wjg.v21.i36.10299
Peer-review started: April 21, 2015
First decision: May 18, 2015
Revised: July 11, 2015
Accepted: August 30, 2015
Article in press: August 31, 2015
Published online: September 28, 2015
Core tip: Hepatitis C virus (HCV) and lipids interact closely at multiple stages in the HCV life cycle. HCV infection may have a profound influence on lipid metabolism, while lipids can regulate HCV replication. Infectious HCV forms lipo-viral particles that possess the features of lipoproteins. Examination of lipoprotein sub-fractions and apolipoproteins is inevitable for evaluating the nature of disturbed lipid metabolism. Among apolipoproteins, apolipoprotein E is a key molecule required for HCV entry, and is one of the possible therapeutic targets for interrupting HCV infection. Understanding the disturbed lipid metabolism may shed light on the pathophysiology of HCV infection and help develop novel therapeutics.