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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2015; 21(3): 913-918
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.913
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.913
Association of nonalcoholic fatty liver disease and liver cancer
Perla Oliveira Schulz, Andrea Vieira, Gastroenterology Service, Internal Medicine Department, Santa Casa School of Medical Sciences, São Paulo 01277-900, Brazil
Maria de Fátima Araújo Nascimento, Pathology Department, Santa Casa School of Medical Sciences, São Paulo 01277-900, Brazil
André Ibrahim David, GI Transplant Service, Gastroenterology Department, University of São Paulo, São Paulo 01246-903, Brazil
Fabio Gonçalves Ferreira, Mauricio Alves Ribeiro, Luiz Arnaldo Szutan, Department of Surgery, Liver and Portal Hypertension Group, Santa Casa School of Medical Sciences, São Paulo 01277-900, Brazil
Author contributions: Schulz PO performed the research and collected and analyzed the data; Ferreira FG contributed to the design of the study; Nascimento MFA performed the histological analysis; Vieira A, Ribeiro MA, David AI and Szutan LA contributed to the design of the study and analysis of the data; Schulz PO and Ferreira FG wrote the manuscript.
Supported by CAPES-MEC-Brazil - Grant master’s thesis.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Fabio Gonçalves Ferreira, MD, PhD, Department of Surgery, Liver and Portal Hypertension Group, Santa Casa School of Medical Sciences, R Apinajes, 1060 ap 93, São Paulo 01277-900, Brazil. drfabioferreira@uol.com.br
Telephone: +55-11-992110057 Fax: +55-11-33378164
Received: June 3, 2014
Peer-review started: June 3, 2014
First decision: June 27, 2014
Revised: July 18, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: January 21, 2015
Peer-review started: June 3, 2014
First decision: June 27, 2014
Revised: July 18, 2014
Accepted: September 18, 2014
Article in press: September 19, 2014
Published online: January 21, 2015
Core Tip
Core tip: There has not been a study clearly showing a relation between the nonalcoholic steatohepatitis cirrhosis and hepatocellular carcinoma (HCC). Some studies have suggested that the early stage of hepatic steatosis can be a favorable microenvironment for the development of liver metastases of colorectal cancer (LMCC). Others have suggested that hepatic steatosis has a protective role in the development of LMCC. Our analysis of the association of nonalcoholic fatty liver disease (NAFLD) with liver primary and secondary malignancies found a statistically higher prevalence of NAFLD in patients with LMCC, but not in non-cirrhotic HCC patients.