Case Control Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jan 21, 2015; 21(3): 905-912
Published online Jan 21, 2015. doi: 10.3748/wjg.v21.i3.905
RhoC, vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma
Zhi-Hua Zhao, Yan Tian, Jian-Pin Yang, Jun Zhou, Kui-Sheng Chen
Zhi-Hua Zhao, Yan Tian, Jian-Pin Yang, Jun Zhou, Kui-Sheng Chen, Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Author contributions: Zhao ZH, Tian Y and Chen KS designed the research; Zhao ZH, Tian Y, Chen KS, Yang JP and Zhou J performed the research; Zhao ZH, Tian Y and Chen KS contributed new reagents or analytic tools; Zhao ZH and Tian Y analyzed the data; Zhao ZH and Tian Y wrote the paper.
Supported by First Affiliated Hospital of Zhengzhou University, Henan-based Research Projects with Cutting-Edge Technology, No. 132300410126 and No. 132300410458.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kui-Sheng Chen, MD, Professor, Department of Pathology, the First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Rd, Erqi District, Zhengzhou 450052, Henan Province, China. 15036607301@163.com
Telephone: +86-371-66658175 Fax: +86-371-66658175
Received: March 27, 2014
Peer-review started: March 27, 2014
First decision: August 6, 2014
Revised: August 23, 2014
Accepted: November 8, 2014
Article in press: November 11, 2014
Published online: January 21, 2015
Core Tip

Core tip: Recent studies have found that Ras homolog (Rho)C plays an important role in promoting angiogenesis in breast cancer. RhoC overexpression in breast cancer epithelial cells can improve expression of vascular endothelial growth factor (VEGF) and other angiogenic factors. Detection of the expression of RhoC, VEGF and microvascular density in esophageal squamous cell carcinoma and the relationship with metastasis and invasion have not been reported.