Ezetimibe improves hepatic steatosis in relation to autophagy in obese and diabetic rats
Eugene Chang, Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 120-750, South Korea
Lisa Kim, Diabetes Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, South Korea
Se Eun Park, Eun-Jung Rhee, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Cheol-Young Park, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul 110-746, South Korea
Cheol-Young Park, Diabetes Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 110-746, South Korea
Author contributions: Chang E conceived and designed the experimental study, conducted the experiments, performed the data analysis, and wrote the manuscript; Kim L conducted the experiments; Park SE, Rhee EJ, Lee WY, Oh KW and Park SW contributed to the discussion; and Park CY directed the study and revised the manuscript.
Supported by Samsung Biomedical Research Institute, Grant No. SBRI C-B1-111-3; National Research Foundation of Korea, No. 2012R1A1A2009143/2013027171; and Korean Diabetes Association (to Park CY, 2014S-1)
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of Kangbuk Samsung Hospital, Sungkyunkwan University (IACUC protocol number: 201010014).
Conflict-of-interest statement: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Cheol-Young Park, MD, PhD, Division of Endocrinology and Metabolism, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, No. 108, Pyung-Dong, Jongno-Ku, Seoul 110-746, South Korea. email@example.com
Telephone: +82-2-20011869 Fax: +82-2-20011588
Received: August 31, 2014
Peer-review started: September 1, 2014
First decision: September 27, 2014
Revised: November 18, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: July 7, 2015