Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.541
Peer-review started: May 8, 2014
First decision: May 29, 2014
Revised: June 17, 2014
Accepted: July 22, 2014
Article in press: July 22, 2014
Published online: January 14, 2015
Core tip: The exact roles of pre-core (pre-C) and basal core promoter (BCP) mutations remain unclear before and after hepatitis B e antigen (HBeAg) seroconversion. Here, although the pre-C mutant became predominant in the HBeAg seroconversion group during follow-up, the proportion of the BCP mutation did not change. Hepatitis B virus (HBV) viral markers were significantly higher in patients without the mutations in an HBeAg positive status. HBV DNA and hepatitis B surface antigen levels were higher in patients with the pre-C mutation in an anti-HBe positive status. Taken together, the association of the pre-C mutation on viral load appears to be opposite before and after HBeAg seroconversion in patients with HBV infection.