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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. May 21, 2015; 21(19): 6052-6059
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.6052
Published online May 21, 2015. doi: 10.3748/wjg.v21.i19.6052
Associations between CD24 gene polymorphisms and inflammatory bowel disease: A meta-analysis
Xiao-Li Huang, Department of Gastroenterology, Gulou School of Clinical Medicine, Nanjing Medical University, Nanjing 210008, Jiangsu Province, China
Xiao-Li Huang, Guo-Pin Wang, Department of Gastroenterology, Nanjing Jiangbei People’s Hospital Affiliated to Southeast University, Nanjing 210048, Jiangsu Province, China
Dong-Hua Xu, Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
Shu Zhang, Nanjing University Medical School, Nanjing 210093, Jiangsu Province, China
Cheng-Gong Yu, Department of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China
Author contributions: Huang XL and Xu DH contributed equally to this work; Huang XL and Xu DH performed the research; Wang GP and Zhang S were involved in editing the manuscript; Yu CG designed the study and revised the manuscript as the corresponding author.
Conflict-of-interest: The authors declare that there is no conflict of interests regarding the publication of this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Cheng-Gong Yu, MD, PhD, Department of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, Jiangsu Province, China. chenggong_yu@nju.edu.cn
Telephone: +86-25-83106666 Fax: +86-25-83105206
Received: October 21, 2014
Peer-review started: October 27, 2014
First decision: November 18, 2014
Revised: December 20, 2014
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: May 21, 2015
Peer-review started: October 27, 2014
First decision: November 18, 2014
Revised: December 20, 2014
Accepted: February 12, 2015
Article in press: February 13, 2015
Published online: May 21, 2015
Core Tip
Core tip: CD24 is a significant immune regulatory mediator of inflammatory bowel disease (IBD). Some recent studies have demonstrated that CD24 gene polymorphisms are associated with the susceptibility to IBD, but the findings of other studies are contradictory. The present study sought to provide a more precise estimate of this potential association. A meta-analysis of Caucasian cohorts found that the CD24 C170T polymorphism was associated with the susceptibility to UC and that the CD24 TG1527del polymorphism was associated with CD.