Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2015; 21(12): 3706-3710
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3706
Prognostic value of c-Met in colorectal cancer: A meta-analysis
Yan Liu, Xiao-Feng Yu, Jian Zou, Zi-Hua Luo
Yan Liu, Xiao-Feng Yu, Jian Zou, Zi-Hua Luo, Department of Gastroenterology, Huadong Hospital, Fudan University, Shanghai 200040, China
Author contributions: Liu Y and Yu XF conceived the study; Zou J and Luo ZF collected data and performed data analysis; Liu Y and Yu XF wrote the paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Xiao-Feng Yu, Professor, Department of Gastroenterology, Huadong Hospital, Fudan University, 221 Yanan Xi Road, Shanghai 200040, China.
Telephone: +86-21-62484981 Fax: +86-21-62484981
Received: September 3, 2014
Peer-review started: September 4, 2014
First decision: October 14, 2014
Revised: October 31, 2014
Accepted: December 1, 2014
Article in press: December 1, 2014
Published online: March 28, 2015
Core Tip

Core tip: High c-Met expression was found in colorectal cancer and showed a positive relationship with early tumor invasion and metastasis. However, there still seems to be no consensus about the prognostic properties of c-Met status. In this paper, after combing the data from 11 retrospective studies with 1,895 patients, the authors found that high c-Met expression was associated with poor prognosis in patients with colorectal cancer.