Published online Mar 21, 2015. doi: 10.3748/wjg.v21.i11.3214
Peer-review started: October 20, 2014
First decision: December 11, 2014
Revised: December 29, 2014
Accepted: January 30, 2015
Article in press: January 30, 2015
Published online: March 21, 2015
Core tip: Nonalcoholic fatty liver disease (NAFLD) is a progressive disorder that can lead to impaired liver function and, ultimately, liver failure. The ghrelin-ghrelin O-acyltransferase (GOAT) system has recently been found to play a crucial role in both the development of steatosis and its progression to nonalcoholic steatohepatitis. This review probes into the possible relationship between ghrelin-GOAT system and NAFLD, and considers the potential mechanisms by which the ghrelin-GOAT system brings about insulin resistance and other aspects concerning NAFLD.