Copyright
©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 28, 2014; 20(48): 18404-18412
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18404
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18404
Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer
Xiao-Li Wei, De-Shen Wang, Dong-Liang Chen, Zhao-Lei Zeng, Ying Jin, Feng Wang, Miao-Zhen Qiu, Hui-Yan Luo, Dong-Sheng Zhang, Rui-Hua Xu, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong Province, China
Shao-Yan Xi, Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, Guangdong Province, China
Wen-Jing Wu, Department of Breast Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, Guangdong Province, China
Rui-Yu Wang, Ya-Xin Huang, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China
Author contributions: Wei XL, Wang DS and Xi SY contributed equally to the study; Wei XL and Wang DS drafted the manuscript; Wei XL, Wang RY and Huang YX collected the clinical data of the colorectal cancer patients; Xi SY, Wu WJ, Wang DS and Zeng ZL performed the immunohistochemical staining; Wang F, Qiu MZ and Luo HY collected tumor slices; Xi SY and Zhang DS reviewed the pathologic slices and scored the immunohistochemical staining; Jin Y and Wang F performed the statistical analysis; Xu RH conceived, designed and coordinated the study, and offered help with preparation of the manuscript; all authors have read and approved the final manuscript.
Supported by National High Technology Research and Development Program of China (863 Program), No. 2012AA02A506; National Natural Science Foundation of China, No. 81372570; the Science and Technology Foundation of Guangdong Province, China, No. 2012B031800088; and the Science and Technology Foundation of Guangdong Province, China, No. C2011019
Correspondence to: Rui-Hua Xu, MD, PhD, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dong Feng Road East, Guangzhou 510060, Guangdong Province, China. xurh@sysucc.org.cn
Telephone: +86-20-87343468 Fax: +86-20-87343468
Received: May 21, 2014
Revised: June 29, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Revised: June 29, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Core Tip
Core tip: AT-rich interactive domain 1A (ARID1A) (BAF250A) is a member of the switching defective/sucrose non-fermenting (BAF) complexes, which remodel nucleosomes. ARID1A gene mutation and protein loss have been detected in many human cancers. However, research on their clinical association in colorectal cancer is limited and requires further exploration. We found that ARID1A loss was not rare in primary colorectal cancer tumors (25.8%), and it was associated with clinicopathologic characteristics in colorectal cancer patients and with survival in stage IV patients.