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World J Gastroenterol. Dec 28, 2014; 20(48): 18346-18353
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18346
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18346
Zinc finger protein 139 expression in gastric cancer and its clinical significance
Yong Li, Qun Zhao, Li-Qiao Fan, Li-Li Wang, Bi-Bo Tan, Yan-Li Leng, Yu Liu, Dong Wang, Department of General Surgery, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Li Y designed research; Zhao Q, Fan LQ, Wang LL and Wang D collected clinical data and performed the research; Tan BB, Leng YL and Liu Y performed the experiments; Tan BB and Leng YL analyzed the data; Li Y, Tan BB and Leng YL wrote the paper.
Supported by National Natural Science Foundation of China, No. 81072033 and No. 81372580; Natural Science Foundation of Hebei Province, No. C2010000619; Extra Characteristic Foundation of Colleges and Universities in Hebei Province, No. [2005]52; and the Health Department of Hebei Province, No. 20110460
Correspondence to: Yong Li, Professor, Department of General Surgery, The Fourth Hospital, Hebei Medical University, Jiankang Road 12, Shijiazhuang 050011, Hebei Province, China. li_yong_hbth@126.com
Telephone: +86-311-86095678 Fax: +86-311-86077634
Received: April 7, 2014
Revised: May 30, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Revised: May 30, 2014
Accepted: July 16, 2014
Published online: December 28, 2014
Core Tip
Core tip: We investigated the expression of zinc finger protein 139 (ZNF139) in gastric cancer (GC), and analyzed its clinical significance. The results show that ZNF139 is overexpressed in GC tissues, and is related to clinicopathologic characteristics and prognosis of GC. ZNF139 may be involved in apoptosis in GC tissues by regulating caspase-3.