Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer

doi:10.3748/wjg.v20.i48.18338

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Dec 28, 2014 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2014; 20(48): 18338-18345
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18338

Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer

Zhi-Hui Yan, Li-Hong Cui, Xiao-Hui Wang, Chao Li, Xing He

Zhi-Hui Yan, Li-Hong Cui, Xiao-Hui Wang, Chao Li, Xing He, Department of Gastroenterology, Navy General Hospital of PLA, Beijing 100048, China

Author contributions: Yan ZH and Cui LH contributed equally to this work; all authors contributed to the manuscript.

Supported by Capital Public Health Project Cultivation Program, No. Z111107067311051

Correspondence to: Li-Hong Cui, PhD,MD, Department of Gastroenterology, Navy General Hospital of PLA, 6 Fucheng Road, Beijing 100048, China. luckycui861@sina.com

Telephone: +86-10-66957541 Fax: +86-10-68780570

Received: June 8, 2014
Revised: July 12, 2014
Accepted: August 13, 2014
Published online: December 28, 2014

Core Tip

Core tip: This study selects the blood and tissue samples of neoplastic polyps, colorectal cancer and normal tissues for related gene sequencing. By comparing the differences in SNPs, the genetics and pathogenesis of colorectal cancer are analyzed.