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World J Gastroenterol. Dec 28, 2014; 20(48): 18207-18215
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18207
Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18207
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling
Emilien Loeuillard, Julien Bertrand, Anni Herranen, Chloé Melchior, Charlène Guérin, Moïse Coëffier, Pierre Déchelotte, Guillaume Savoye, Rachel Marion-Letellier, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, Rouen Cedex 76183, France
Emilien Loeuillard, Julien Bertrand, Anni Herranen, Chloé Melchior, Charlène Guérin, Moïse Coëffier, Pierre Déchelotte, Guillaume Savoye, Rachel Marion-Letellier, Institute for Research and Innovation in Biomedicine, University of Rouen, Rouen Cedex 76183, France
Chloé Melchior, Guillaume Savoye, Department of Gastroenterology, Rouen University Hospital, Rouen Cedex 76183, France
Moïse Coëffier, Pierre Déchelotte, Nutrition Unit, Rouen University Hospital, Rouen Cedex 76183, France
Moutaz Aziz, Department of Pathology, Rouen University Hospital, Rouen Cedex 76183, France
Author contributions: Déchelotte P, Savoye G and Marion-Letellier R designed the research; Loeuillard E, Bertrand J, Herranen A, Melchior C, Guérin C, Aziz M and Marion-Letellier R performed the research; Loeuillard E, Bertrand J, Coëffier M, Savoye G and Marion-Letellier R analyzed the data; and Savoye G and Marion-Letellier R wrote the paper.
Correspondence to: Rachel Marion-Letellier, PhD, INSERM Unit UMR1073, Rouen University and Rouen University Hospital, 22, Boulevard Gambetta, Rouen Cedex 76183, France. marion_rachel@hotmail.com
Telephone: +33-2-35148245 Fax: +33-2-35148226
Received: May 5, 2014
Revised: June 30, 2014
Accepted: September 5, 2014
Published online: December 28, 2014
Revised: June 30, 2014
Accepted: September 5, 2014
Published online: December 28, 2014
Core Tip
Core tip: Inflammatory bowel disease gives rise to challenging clinical conditions, and many patients have to undergo surgery throughout their life due to irreversible lesions. As no specific treatment is currently available for intestinal fibrosis, we tested an antifibrotic drug that is effective in other chronic inflammatory diseases. In the present study, we found that rats with 2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis exhibited colon fibrosis associated with high expression of transforming growth factor-β signaling, particularly in the Akt pathway. Nevertheless, we failed to inhibit colon fibrosis by proteasome inhibition in our experimental conditions.