Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18131
Revised: September 22, 2014
Accepted: November 7, 2014
Published online: December 28, 2014
Core tip: Liver biopsy is the current best available standard of reference to diagnose liver fibrosis, but it has several limits. Non-invasive methods to detect and follow up liver fibrosis (direct and indirect serum markers, ultrasound, ultrasound doppler, contrast enhanced ultrasound and Elastography) have been extensively studied in the last years but strong evidences of their usefulness in the real practice are still lacking. This work aims to review the most recent literature about the use of these non-invasive markers in defining liver fibrosis.