Published online Dec 28, 2014. doi: 10.3748/wjg.v20.i48.18070
Revised: October 21, 2014
Accepted: November 18, 2014
Published online: December 28, 2014
Core tip: The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is still not fully elucidated. We explored the role of the following adipocytokines and proinflammatory cytokines in the pathogenesis of NAFLD: adiponectin, leptin, ghrelin, resistin and visfatin among adipokines, and tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1 among proinflammatory cytokines. Although a definite conclusion is complex, from analyzed data we could conclude that adiponectin, des-acyl ghrelin and leptin are adipokines that decrease, while TNF-α and IL-6 are cytokines that enhance insulin resistance and subsequently NAFLD. Acting on these premises, new therapeutic possibilities emerge; however, much work remains to be done.