Published online Dec 7, 2014. doi: 10.3748/wjg.v20.i45.16902
Revised: April 15, 2014
Accepted: August 13, 2014
Published online: December 7, 2014
Core tip: The pathogenesis of acute pancreatitis is not clear and treatment of this disease is unspecific. Since the severe form of acute pancreatitis often leads to death or to pancreatic insufficiency, the understanding of the mechanisms involved in pancreatic protection appears to be an important problem. Experimental data have shown that pancreatitis severity could be attenuated by various hormones. Herein, we review the results of our research studies and others, as well as data from clinical observations concerning the protective effects of ghrelin, leptin and melatonin on acute pancreatitis. We also present the hypothetical mechanisms responsible for the beneficial influence of these substances on pancreatic inflammation.