NANOG: A promising target for digestive malignant tumors

doi:10.3748/wjg.v20.i36.13071

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Sep 28, 2014 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Sep 28, 2014; 20(36): 13071-13078
Published online Sep 28, 2014. doi: 10.3748/wjg.v20.i36.13071

NANOG: A promising target for digestive malignant tumors

Ai-Xi Sun, Chang-Jiang Liu, Zi-Qin Sun, Zhi Wei

Ai-Xi Sun, Chang-Jiang Liu, Zi-Qin Sun, Zhi Wei, Department of Gastroenterology, The General Hospital of Jinan Military Command, Jinan 250031, Shandong Province, China

Author contributions: Sun AX and Liu CJ equally contributed to this paper; Liu CJ designed the article; Sun ZQ designed and revised the paper; Sun AX wrote the paper; Wei Z revised the paper.

Supported by Natural Science Foundation of Shandong Province, No. ZR2011HM021

Correspondence to: Zi-Qin Sun, MD, PhD, Department of Gastroenterology, The General Hospital of Jinan Military Command, No. 25 Shifan Road, Tianqiao District, Jinan 250031, Shandong Province, China. ziqins@126.com

Telephone: +86-531-51665320 Fax: +86-531-51665254

Received: February 14, 2014
Revised: May 3, 2014
Accepted: June 13, 2014
Published online: September 28, 2014

Core Tip

Core tip: This review article differs from previous reviews by concentrating on the relationship between NANOG and cancer. This review contains the following five sections: the structure of NANOG, NANOG and cancer stem cells, signal pathways associated with NANOG in cancer, NANOG in specific human tumors, and the role of NANOG in anti-cancer therapy. Each section contains novel insights and comprehensively reviews the current literature, which will be very useful to the journal’s readers.