Randomized Controlled Trial
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World J Gastroenterol. Aug 28, 2014; 20(32): 11406-11414
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11406
Glutamine prevents oxidative stress in a model of mesenteric ischemia and reperfusion
Gilmara Pandolfo Zabot, Gustavo Franco Carvalhal, Norma Possa Marroni, Renata Minuzzo Hartmann, Vinícius Duval da Silva, Henrique Sarubbi Fillmann
Gilmara Pandolfo Zabot, Gustavo Franco Carvalhal, Henrique Sarubbi Fillmann, Department of Surgery, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
Norma Possa Marroni, Renata Minuzzo Hartmann, Department of Gastroenterology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS 90035-903, Brazil
Vinícius Duval da Silva, Department of Pathology, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil
Author contributions: Zabot GP and Fillmann HS designed and performed the research, analyzed the data and wrote the paper; Carvalhal GF analyzed the data and wrote the paper; Marroni NP designed the research; Hartmann RM performed the research; da Silva VD analyzed the pathological data; all authors read an approved the final manuscript.
Supported by Grant from Pro-bolsas/PUCRS
Correspondence to: Gilmara Pandolfo Zabot, Ms Sci, Department of Surgery, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Rua Duque de Caxias, 1012/19, Marechal Rondon, Porto Alegre, RS 90610-000, Brazil. gilmarapandolfo@terra.com.br
Telephone: +55-51-99357780 Fax: +55-51-30317723
Received: January 17, 2014
Revised: March 14, 2014
Accepted: April 30, 2014
Published online: August 28, 2014
Core Tip

Core tip: Ischemia-reperfusion (I/R) leads to oxidative stress, with local and systemic consequences. Many enzymes and interleukins have been implicated in this process, among them interleukin-6 (IL-6) and nuclear factor kappa beta (NF-κB). The exact role of these enzymes is still not clear. Some substances, such as glutamine, have been studied as protective agents against oxidative stress. In an animal experimental model of intestinal I/R we have found that glutamine reduced lipid peroxidation, preserved superoxide dismutase activity, and decreased the expression of IL-6 and NF-κB in both lung and intestine, suggesting a protective role of this amino acid in the setting of intestinal I/R.