Clinical efficacy of tolvaptan for treatment of refractory ascites in liver cirrhosis patients

doi:10.3748/wjg.v20.i32.11400

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 32

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6410)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-3) series, Tables (1-3) series.

Item

Count

PDF

662

WORD

236

HTML

3527

Figures (1-3)

176

Tables (1-3)

137

Sum=4738

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1001

Download

671

Sum=1672

Aug 28, 2014 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (32)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

World J Gastroenterol. Aug 28, 2014; 20(32): 11400-11405
Published online Aug 28, 2014. doi: 10.3748/wjg.v20.i32.11400

Clinical efficacy of tolvaptan for treatment of refractory ascites in liver cirrhosis patients

Xin Zhang, Shu-Zhen Wang, Jun-Fu Zheng, Wen-Min Zhao, Peng Li, Chun-Lei Fan, Bing Li, Pei-Ling Dong, Lei Li, Hui-Guo Ding

Xin Zhang, Shu-Zhen Wang, Jun-Fu Zheng, Wen-Min Zhao, Peng Li, Chun-Lei Fan, Bing Li, Pei-Ling Dong, Lei Li, Hui-Guo Ding, Department of Gastroenterology and Hepatology, Beijing You’an Hospital, Affiliated with Capital Medical University, Beijing 100069, China

Author contributions: Zhang X and Wang SZ contributed equally to the manuscript; Ding HG, Zhang X, Wang SZ and Zheng JF analyzed the data; Zhang X, Wang SZ and Ding HG wrote the manuscript; Ding HG was also responsible for this project and the final revised manuscript; The other authors contributed to data acquisition, patient care and follow up.

Supported by The Program of Beijing Science and Technology Commission, No. D131100005313004; and the Beijing High-Level Talent Academic Leader/Personnel Training Programs awarded to Ding HG, 2011-2-19; Li B, 2013-3-072; and Li L, 2013-3-073

Correspondence to: Hui-Guo Ding, MD, PhD, Director, Department of Gastroenterology and Hepatology, Beijing You’an Hospital, Affiliated with Capital Medical University, Fengtai District, Beijing 100069, China. dinghuiguo@medmail.com.cn

Telephone: +86-10-83997155 Fax: +86-10-63295525

Received: February 8, 2014
Revised: April 11, 2014
Accepted: May 12, 2014
Published online: August 28, 2014

Core Tip

Core tip: This study showed that tolvaptan, a new aquaretic drug, is an effective and safe potential treatment for refractory ascites in patients with decompensated liver cirrhosis, especially in patients with further complications, such as hepatorenal syndrome and/or hepatocellular carcinoma. Tolvaptan significantly increased the serum sodium levels in patients with hyponatremia.