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©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 14, 2014; 20(26): 8729-8735
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8729
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8729
Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas
Shohei Komatsu, Atsushi Takebe, Takumi Fukumoto, Yonson Ku, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan
Takeshi Iwasaki, Department of Surgery, National Hospital Organization, Kobe Medical Center, Hyogo 654-0155, Japan
Yusuke Demizu, Kazuki Terashima, Osamu Fujii, Nobukazu Fuwa, Department of Radiology, Hyogo Ion Beam Medical Center, Hyogo 679-5165, Japan
Akihiro Toyokawa, Department of Surgery, Yodogawa Christian Hospital, Osaka 533-0024, Japan
Kazuhiro Teramura, Department of Pathology, Yodogawa Christian Hospital, Osaka 533-0024, Japan
Author contributions: Komatsu S wrote the manuscript and performed additional data analysis; Iwasaki T helped by supervising and approving the final manuscript; Demizu Y, Terashima K, Fujii O and Fuwa N performed particle radiotherapy; Takebe A, Toyokawa A were attending doctors of the patient; Teramura K made a pathological diagnosis; Fukumoto T and Ku Y developed a new treatment procedure and supervised the manuscript.
Correspondence to: Shohei Komatsu, MD, PhD, Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Hyogo 650-0017, Japan. komasho8@gmail.com
Telephone: +81-78-3826302 Fax: +81-78-3826307
Received: November 19, 2013
Revised: February 10, 2014
Accepted: March 7, 2014
Published online: July 14, 2014
Revised: February 10, 2014
Accepted: March 7, 2014
Published online: July 14, 2014
Core Tip
Core tip: Hepatic epithelioid hemangioendothelioma (HEH) is a rare neoplasm with variable malignant potential. Liver transplantation is the most frequently reported treatment because most patients have multifocal bilobar lesions. Here, we describe a case of a 35-year-old woman with unresectable multiple bilobar HEH that was successfully treated by combination treatment of hepatectomy and carbon-ion radiotherapy. This case demonstrated two significant points: the effectiveness of carbon-ion radiotherapy for HEH and the possibility of expanding the curative treatment options for multiple bilobar hepatic tumors.