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World J Gastroenterol. Jul 14, 2014; 20(26): 8583-8591
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8583
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8583
Prognostic significance of preoperative fibrinogen in patients with colon cancer
Zhen-Qiang Sun, Hai-Jiang Wang, Ze-Liang Zhao, Xian-Bo Yu, Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Zhen-Qiang Sun, Research Laboratory of Disease Genomics, Cancer Research Institute, Central South University, Changsha 410008, Hunan Province, China
Xiao-Na Han, Yong Tang, Yan-Li Qu, Department of Digestive Oncology, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Rui-Wei Xu, Infection and Statistical Office, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China
Yan-Yan Liu, Clinical Pharmacy, Tengzhou Central People’s Hospital, Tengzhou 277500, Shandong Province, China
Author contributions: Sun ZQ, Han XN and Wang HJ conceived and designed the study; Sun ZQ wrote the first draft of the manuscript; Zhao ZL and Yu XB assisted with measurements; Tang Y and Xu RW helped analyze the data; Qu YL and Liu YY collected clinicopathological materials and postoperative samples; all authors read and approved the final manuscript.
Supported by The Science and Technology Innovation Fund of Xinjiang Medical University, No. XJC201267
Correspondence to: Hai-Jiang Wang, MD, Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, 789 Suzhou East Street, Urumqi 830011, Xinjiang Uygur Autonomous Region, China. wanghaijiang0129@163.com
Telephone: +86-991-7819106 Fax: +86-991-3654883
Received: November 5, 2013
Revised: February 22, 2014
Accepted: March 12, 2014
Published online: July 14, 2014
Revised: February 22, 2014
Accepted: March 12, 2014
Published online: July 14, 2014
Core Tip
Core tip: Inflammatory cytokines have been implicated in the development of several malignancies, including colon cancer. Specifically, fibrinogen has been correlated with some clinicopathological factors of cancer. However, the prognostic value of fibrinogen measurements remains unclear, particularly in colon cancer patients. In this study, preoperative fibrinogen levels were correlated with a poor prognosis in a cohort of colon cancer patients. These data suggest that preoperative fibrinogen levels can serve as an independent prognostic factor for colon cancer patients following radical surgery.