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World J Gastroenterol. Jun 14, 2014; 20(22): 6981-6988
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6981
Published online Jun 14, 2014. doi: 10.3748/wjg.v20.i22.6981
Should peri-gastrectomy gastric acidity be our focus among gastric cancer patients?
Lei Huang, A-Man Xu, Wen-Xiu Han, Jing Xu, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Tuan-Jie Li, Department of General Surgery, NanFang Hospital of Southern Medical University, Guangzhou 510515, Guangdong Province, China
Author contributions: Huang L, Xu AM, Li TJ, Han WX and Xu J designed the research; Huang L, Li TJ and Xu J performed the research; Han WX and Xu J contributed analytic tools; Huang L and Li TJ analyzed the data; Huang L and Xu AM wrote the paper.
Supported by National Natural Science Foundation of China, No. 81172036; Foundation of Anhui Science and Technology Agency, No. 12070403061
Correspondence to: A-Man Xu, MD, Professor, Chief Physician, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, No. 218, Jixi Road, Hefei 230022, Anhui Province, China. hlzt1991@sina.com
Telephone: +86-551-65334247 Fax: +86-551-63633742
Received: November 8, 2013
Revised: February 19, 2014
Accepted: March 19, 2014
Published online: June 14, 2014
Revised: February 19, 2014
Accepted: March 19, 2014
Published online: June 14, 2014
Core Tip
Core tip: Necessity of peri-gastrectomy acid suppression for gastric cancer patients remains controversial. This innovative prospective study showed: before surgery, gastric pH was higher than the threshold of hypoacidity, and affected by age, tumor size and differentiation grade, and potassium and bicarbonate ions; advanced malignancies were accompanied with higher pH; after operation, gastric pH in all groups was of weak-acidity and higher than that pre-gastrectomy; six months later, gastric pH was comparable to that on days 3-5; reflux symptom was significantly associated with patient’s body mass index, direct and indirect bilirubin, and total bile acid, while pH played no role.