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World J Gastroenterol. May 14, 2014; 20(18): 5191-5204
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5191
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5191
History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer
David Y Graham, Michael E DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX 77030, United States
Author contributions: Graham DY wrote this work without assistance.
Supported by In part by the Office of Research and Development Medical Research Service Department of Veterans Affairs, Public Health Service grants No. DK062813 and No. DK56338 which funds the Texas Medical Center Digestive Diseases Center
Correspondence to: David Y Graham, MD, Michael E DeBakey VA Medical Center, Baylor College of Medicine, 2002 Holcombe Blvd., Rm 3A-318B (111D), Houston, TX 77030, United States. dgraham@bcm.edu
Telephone: +1-713-7950232 Fax: +1-713-7901040
Received: September 26, 2013
Revised: October 28, 2013
Accepted: January 14, 2014
Published online: May 14, 2014
Revised: October 28, 2013
Accepted: January 14, 2014
Published online: May 14, 2014
Core Tip
Core tip:Helicobacter pylori (H. pylori)-related diseases reflect the pattern and extent of gastritis/atrophy (i.e., duodenal ulcer signifies the presence of non-atrophic gastritis whereas gastric ulcer and gastric cancer signify atrophic gastritis). While, it has been suggested that gastric ulcer and duodenal ulcer both arose or became more frequent in Europe in the 19th century, the available data are more consistent with a change in the pattern of gastritis related to environmental conditions which previously had resulted primarily in atrophic gastritis. Duodenal ulcer then dominated clinically until the rapid decline in H. pylori transmission resulted in a rapid decline in all H. pylori-related diseases.