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World J Gastroenterol. Apr 28, 2014; 20(16): 4702-4711
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4702
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4702
Controlled attenuation parameter for non-invasive assessment of hepatic steatosis in Chinese patients
Feng Shen, Qin Pan, Guang-Yu Chen, Hai-Xia Cao, Yi Cao, Rui-Nan Zhang, Lei-Ming Xu, Jian-Gao Fan, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Rui-Dan Zheng, Jian-Neng Chen, Research and Therapy Center for Liver Diseases, The Affiliated Dongnan Hospital of Xiamen University, Zhangzhou 363000, Fujian Province, China
Yu-Qiang Mi, Liang Xu, Tianjin Research Institute of Liver Diseases, Tianjin Hospital of Infectious Diseases, Tianjin 300192, China
Xiao-Ying Wang, Department of Pathology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Ming-Li Chen, Department of UItrasound, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Author contributions: Shen F, Zheng RD, Mi YQ and Fan JG designed the study; Shen F, Wang XY, Chen GY, Cao HX, Chen ML, Xu L and Chen JN performed the research; Pan Q, Chen GY, Cao Y and Zhang RN carried out statistical analysis; Shen F, Xu LM and Fan JG wrote the manuscript; all the authors have read and approved the final revision to be published.
Supported by The National Key Basic Research Project, No. 2012CB517501; Chinese Foundation for Hepatitis Prevention and Control –“WANG Bao-En” Liver Fibrosis Research Fund, No. XJS20120501; Shanghai Science and Technology Committee, No. 09140903500 and No. 10411956300; and the 100-Talents Program of the Shanghai Municipal Health Bureau, No. XBR2011007
Correspondence to: Jian-Gao Fan, MD, PhD, Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, 1665 Kongjiang Road, Shanghai 200092, China. fanjiangao@gmail.com
Telephone: +86-21-25077340 Fax: +86-21-25077340
Received: October 24, 2013
Revised: December 25, 2013
Accepted: February 26, 2014
Published online: April 28, 2014
Revised: December 25, 2013
Accepted: February 26, 2014
Published online: April 28, 2014
Core Tip
Core tip: We introduced a novel controlled attenuation parameter (CAP) which was acquired using the FibroScan® equipped with the M probe. This multi-center prospective cohort study was performed in Chinese nonalcoholic fatty liver disease or chronic hepatitis B patients. Following multivariate linear regression analysis, we found that CAP was significantly correlated with steatosis grade and was not influenced by inflammation, fibrosis or aetiology. Although it is less effective in identifying moderate to severe steatosis and limited by body mass index, we believe that CAP values are more useful than the measurement of 5% steatosis and may be used as a substitute for ultrasonography in epidemiological investigations of fatty liver.