Papa A, Gerardi V, Marzo M, Felice C, Rapaccini GL, Gasbarrini A. Venous thromboembolism in patients with inflammatory bowel disease: Focus on prevention and treatment. World J Gastroenterol 2014; 20(12): 3173-3179 [PMID: 24695669 DOI: 10.3748/wjg.v20.i12.3173]
Corresponding Author of This Article
Alfredo Papa, MD, Internal Medicine and Gastroenterology Unit, Complesso Integrato Columbus, Catholic University, Via G. Moscati 31-33, 00168 Rome, Italy. apapa@rm.unicatt.it
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Mar 28, 2014; 20(12): 3173-3179 Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3173
Venous thromboembolism in patients with inflammatory bowel disease: Focus on prevention and treatment
Alfredo Papa, Viviana Gerardi, Manuela Marzo, Carla Felice, Gian Lodovico Rapaccini, Antonio Gasbarrini
Alfredo Papa, Viviana Gerardi, Manuela Marzo, Carla Felice, Gian Lodovico Rapaccini, Antonio Gasbarrini, Internal Medicine and Gastroenterology Unit, Catholic University, 00168 Rome, Italy
Author contributions: Papa A, Gerardi V, Marzo M and Felice C Substantial contributions to the study conception and design, acquisition of data, or analysis and interpretation of data; Papa A, Gerardi V, Rapaccini GL and Gasbarrini A drafting the article or revising it critically for important intellectual content; Papa A, Gerardi V, Marzo M, Felice C, Rapaccini GL and Gasbarrini A final approval of the version to be published.
Correspondence to: Alfredo Papa, MD, Internal Medicine and Gastroenterology Unit, Complesso Integrato Columbus, Catholic University, Via G. Moscati 31-33, 00168 Rome, Italy. apapa@rm.unicatt.it
Telephone: +39-6-3503310 Fax: +39-6-3503310
Received: October 5, 2013 Revised: December 9, 2013 Accepted: January 14, 2014 Published online: March 28, 2014
Core Tip
Core tip: Inflammatory bowel diseases (IBD) patients have an increased risk of venous thromboembolism (VTE) that represents a significant cause of morbidity and mortality. The prevention of VTE involves the correction of modifiable risk factors, such as: disease activity, vitamin deficiency, dehydration and prolonged immobilization. Essential is also the role of mechanical and pharmacological prophylaxis. However, thromboprophylaxis in IBD patients, although guideline-recommended is still poorly implemented because of concerns about its safety and, over all, the lack of awareness of the magnitude of thrombotic risk in these patients. Further efforts are required to increase the rate of pharmacological prevention of VTE in IBD so to avoid some preventable morbidity and mortality.
