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World J Gastroenterol. Nov 14, 2013; 19(42): 7369-7373
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7369
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7369
Intestinal acyl-CoA synthetase 5: Activation of long chain fatty acids and behind
Christina Klaus, Min Kyung Jeon, Elke Kaemmerer, Nikolaus Gassler, Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany
Author contributions: Klaus C and Gassler N designed and wrote the article; Jeon MK and Kaemmerer E critically reviewed the literature and made technical notes.
Correspondence to: Nikolaus Gassler, Professor, Institute of Pathology, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. ngassler@ukaachen.de
Telephone: +49-241-8088897 Fax: +49-241-8082439
Received: June 21, 2013
Revised: July 20, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Revised: July 20, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Core Tip
Core tip: Acyl-CoA synthetase 5 (ACSL5) activates long-chain fatty acids by coenzyme A linkage and plays a key role in fatty acid metabolism. On the basis of its mitochondrial localization, ACSL5 forms an exceptional member among the acyl-CoA synthetase family. Although its various functions are not yet fully understood, ACSL5 seems to represent a modifier of cellular vitality along the crypt-villus-axis.