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World J Gastroenterol. Nov 14, 2013; 19(42): 7361-7368
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7361
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7361
Role of cyclooxygenase-2 in gastric cancer development and progression
Jian Cheng, Xiao-Ming Fan, Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, Shanghai 201508, China
Author contributions: Fan XM conceived the topic and revised the paper; Cheng J reviewed the literature and wrote the paper.
Supported by Research Grant for Key Clinical Discipline Construction of Shanghai Municipality, China, No. ZK2012B20
Correspondence to: Xiao-Ming Fan, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Jinshan Hospital of Fudan University, No. 1508, Longhang Road, Shanghai 201508, China. xiaomingfan57@sina.com
Telephone: +86-21-34189990 Fax: +86-21-57943141
Received: July 21, 2013
Revised: September 17, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Revised: September 17, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Core Tip
Core tip: Cyclooxygenase-2 (COX-2) plays an important role in gastric cancer development and progression. The present review aims to determine the molecular mechanism of COX-2 overexpression in gastric cancer and focus on the detailed information on COX-2 involved in carcinogenesis. By reviewing research progress, this may be helpful in clarifying the internal relationship of the afore-mentioned aspects.