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World J Gastroenterol. Oct 7, 2013; 19(37): 6178-6187
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6178
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6178
Cytokeratin 8 is increased in hepatitis C virus cells and its ectopic expression induces apoptosis of SMMC7721 cells
Ming-Zhu Sun, Shuang-Suo Dang, Wen-Jun Wang, Xiao-Li Jia, Song Zhai, Xin Zhang, Mei Li, Ya-Ping Li, Department of Infectious Diseases, the Second Affiliated Hospital of College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Ming-Zhu Sun, Shuang-Suo Dang, Wen-Jun Wang, Xiao-Li Jia, Song Zhai, Xin Zhang, Mei Li, Ya-Ping Li, Department of Epidemiology and Biostatistics, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Meng Xun, Department of Immunology and Pathogen Biology, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China
Author contributions: Sun MZ wrote the manuscript; Dang SS supervised the research process and revised the manuscript; Wang WJ critically revised the manuscript; Jia XL, Zhai S, Zhang X, Li M, Li YP and Xun M collected data; all authors have read and approved the final version to be published.
Supported by National Natural Science Foundation of China, No.81170393
Correspondence to: Shuang-Suo Dang, PhD, Professor, Director of Department of Infectious Diseases, the Second Affiliated Hospital of College of Medicine, Xi’an Jiaotong University, No. 157, Xi Wu Road, Xi’an 710004, Shaanxi Province, China. dang212@126.com
Telephone: +86-29-87679688 Fax: +86-29-87679688
Received: June 30, 2013
Revised: August 10, 2013
Accepted: August 16, 2013
Published online: October 7, 2013
Revised: August 10, 2013
Accepted: August 16, 2013
Published online: October 7, 2013
Core Tip
Core tip: In this study, we observed that cytokeratin 8 (CK8) levels are elevated in hepatitis C virus (HCV) cell culture system and its ectopic expression decreased the proliferation and induced apoptosis of SMMC7721 cells. CK8 up-regulation might have a functional role in HCV infection and pathogenesis, and could be a promising target for the treatment of HCV infection.