Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5150
Revised: May 24, 2013
Accepted: July 4, 2013
Published online: August 21, 2013
Core tip: The presence or absence of lymph node metastasis is an important prognostic factor in patients with curatively resected gallbladder cancer (GBC). The present study evaluates the prognostic impact of number, location and ratio of involved lymph nodes, in addition to well described prognostic parameters, in patients with curatively resected GBC. The results demonstrate that total lymph node count and lymph node ratio are more appropriate to stratify GBC patients with regards to prognosis; removal and pathological examination of at least six lymph nodes can influence staging quality and disease-specific survival especially in node-positive patients.