Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5144
Revised: March 28, 2013
Accepted: July 17, 2013
Published online: August 21, 2013
Core tip: We analyzed the relationship between the high mobility group box chromosomal protein 1 (HMGB1) 1176 G/C polymorphism and the susceptibility and outcome to hepatitis B virus (HBV) infection in a large hospital-based case-control study. Our results indicated that patients with 1176G/G genotype of HMGB1 gene are more likely to have a progressive status in HBV infection. Our study emphasizes the importance of HMGB1 in the pathophysiology of HBV-related diseases on the population level and will provide researchers new clue for the further basic research in pathogenesis of chronic HBV infection.