Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5029
Revised: July 12, 2013
Accepted: July 18, 2013
Published online: August 21, 2013
Core tip: Ursodeoxycholic acid can be considered one of the less expensive, best tested and safest of the drugs currently available. This editorial is aimed to provide a brief review of the principal non-invasive non-surgical medical treatments for cholesterol gallstones. Based on the literature and on our experimental and clinical works we try to summarize the recent developments in ursodeoxycholic acid use, current indications for its use and the more recent advances in understanding its effects in terms of an anti-inflammatory drug. For these reasons, the story would not appear to end herewith but deserves further attention and investigation.