Published online May 14, 2013. doi: 10.3748/wjg.v19.i18.2818
Revised: March 14, 2013
Accepted: March 23, 2013
Published online: May 14, 2013
Core tip: This study included three groups, acute-on-chronic hepatitis B liver failure (ACHBLF) patients, chronic hepatitis B (CHB) patients and healthy controls. Flow cytometry was used to analyze the frequency of CD163+ peripheral blood mononuclear cells (PBMCs) and surface protein expression of CD163. Real-time transcription-polymerase chain reaction was performed to assess relative CD163 mRNA levels in PBMCs. The population of CD163+ PBMCs was significantly larger in ACHBLF patients than in CHB patients and healthy controls. CD163 mRNA expression in ACHBLF patients was significantly increased compared with healthy controls. Plasma soluble CD163 (sCD163) levels were markedly increased and correlated with disease severity and prognosis in ACHBLF patients. CD163 and sCD163 may be useful biomarkers for ACHBLF.