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World J Gastroenterol. Apr 21, 2013; 19(15): 2340-2347
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2340
Published online Apr 21, 2013. doi: 10.3748/wjg.v19.i15.2340
Depletion of telomerase RNA inhibits growth of gastrointestinal tumors transplanted in mice
Xue-Cheng Sun, Xiao-Hua Ye, Department of Gastroenterology and Hepatology, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Jing-Yi Yan, Xiao-Lei Chen, Ying-Peng Huang, Xian Shen, Department of Gastroenterology and General Surgery, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, Zhejiang Province, China
Author contributions: Sun XC and Yan JY performed the majority of experiments; Huang YP and Shen X provided vital reagents and analytical tools; Ye XH was involved in editing the manuscript; Chen XL designed the study and wrote the manuscript.
Supported by The Natural Science Foundation of Zhejiang Province, No. Y201016273
Correspondence to: Jing-Yi Yan, Associate Chief Physician, Department of Gastroenterology and General Surgery, the First Affiliated Hospital of Wenzhou Medical College, No 2 Fuxue Road, Wenzhou 325000, Zhejiang Province, China. yjy751231@126.com
Telephone: +86-577-88069555 Fax: +86-577-88069555
Received: December 13, 2012
Revised: February 14, 2013
Accepted: March 22, 2013
Published online: April 21, 2013
Revised: February 14, 2013
Accepted: March 22, 2013
Published online: April 21, 2013
Core Tip
Core tip: Gastrointestinal stromal tumors (GISTs) are low-grade malignant mesenchymal tumors of the gastrointestinal tract. In our study, telomerase activity was repressed and the level of B-cell leukemia/lymphoma 2 mRNA markedly downregulated in SCID mice carrying transplanted human GISTs and treated with telomerase RNA-targeting phosphorothioate antisense oligodeoxynucleotides (PS-ASODN). Therefore, the therapeutic effect of PS-ASODN on GISTs is remarkable.