Published online May 21, 2021. doi: 10.3748/wjg.v27.i19.2366
Peer-review started: February 2, 2021
First decision: March 6, 2021
Revised: March 18, 2021
Accepted: April 13, 2021
Article in press: April 13, 2021
Published online: May 21, 2021
Few studies have examined the changes in vitamin nutritional status and their influencing factors during chemotherapy for esophageal cancer (EC). Most vitamins were found to be negatively associated with the risk of colorectal and gastric cancer in addition to EC, yet interventional treatment failed to demonstrate a clear preventive effect in these malignancies. In our study, the effects of chemotherapeutic drugs on EC patients’ vitamin levels and hematological indicators were analyzed.
We analyzed the effects of chemotherapeutic drugs on EC patients’ vitamin levels and hematological indicators by detecting the changes in nine vitamins and hematological indicators before and after chemotherapy, with an attempt to provide evidence for vitamin supplementation. Many oncologists believe that vitamin testing is valuable in tumor patients as it can identify whether there is a specific vitamin deficiency and/or justify vitamin therapy. Our findings may be valuable for the implementation of tailored nutritional interventions.
To explore multiple vitamin levels and the possible influential factors in EC patients treated with chemotherapy. Varying degrees of vitamin deficiency and weight loss were found in these patients. Vitamin supplementation may reduce the adverse effects of chemotherapy.
Vitamin nutritional status was measured using the electrochemiluminescence method with an LK3000VI vitamin detector before and after two cycles of chemotherapy in EC patients. Statistical analysis was performed using the SPSS 24.0 software package. The latent correlations between multiple vitamin levels (the independent variables) and body mass index (the dependent variable) during chemotherapy were analyzed using the Spearman method.
Varying degrees of vitamin A, D, C and B2 deficiency and weight loss were found in EC patients. Statistically significant differences were shown in vitamins A, C, B2 and B6 levels and body mass index before and after chemotherapy. Multivariate analysis showed that vitamin A levels significantly differed between male and female EC patients, whereas vitamin D concentrations significantly differed in EC patients in different stages. Correlations were observed between the changes in serum vitamin A and C levels pre- and postchemotherapy and the variation in body mass index.
Varying degrees of vitamin deficiency and weight loss were found in EC patients undergoing chemotherapy. Vitamin supplementation may help to improve the nutritional status, chemotherapy tolerance and efficacy. To detect the concentrations of vitamins is valuable for EC patients.
A multicenter prospective study should be performed to reveal the suitable vitamin replenishment programs and potential effects on treatment outcomes and the adverse effects of chemotherapy in EC patients. Thus, randomized control studies and intervention are needed to verify our finding.