Published online Oct 15, 2002. doi: 10.3748/wjg.v8.i5.822
Revised: April 2, 2002
Accepted: April 13, 2002
Published online: October 15, 2002
AIM: To investigate the possible roles of p53 and C-myc genes in the primary hepatocellular carcinogenesis and the relationship between the liver hyperplastic nodule (LHN) and hepatocellular carcinoma (HCC).
METHODS: The expression of p53 and C-myc genes was detected immunohist-ochemically in 73 and 60 cases of HCC and pericarcinomatous tissues, respectively.
RESULTS: The positive expression of p53 in HCC was significantly higher than that in pericarcinomatous tissues (P < 0.05). In pericarcinomatous tissues, the p53 expression was observed only in LHN, but not in liver cirrhosis (LC) and normal liver tissues. The positive expression rate of C-myc in HCC or LHN was significantly higher than that in LC or normal liver tissues (P < 0.05 and P < 0.01), however, no significant difference was found between HCC and LHN (P > 0.05). The positive expression rate of p53 and C-myc in HCC was correlated with the histological differentiation, that in the poorly differentiated was significantly higher than that in well differentiated samples (P < 0.05).
CONCLUSION: The overexpression of p53 and C-myc genes might play a role in the carcinogenesis of HCC; And LHN seems a preneoplastic lesion related to hepatocarcinogenesis; No evidence supports that LC contribute directly to the hepatocarcinogenesis.