Original Articles
Copyright ©The Author(s) 1999. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 15, 1999; 5(1): 47-49
Published online Feb 15, 1999. doi: 10.3748/wjg.v5.i1.47
Expression of Cx genes in liver and stomach of different embryonic stages
Jian-Xiang Zhang, Shou-Rong Shen, Xiao-Hui Zhang, Xiang Chen
Jian-Xiang Zhang, Xiao-Hui Zhang, Department of Histology and Embryology, Hunan Medical University, Changsha 410078, Hunan Province, China
Shou-Rong Shen, Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha 410078, Hunan Province, China
Xiang Chen, The First People’s Hospital of Zhaoqing City, Zhaoqing 526000, Guangdong Province, China
Jian-Xiang Zhang, male, born on November 29, 1951 in Changsha City, Hunan Province, graduated from Hunan Medical University with a master degree in histology and embryology, now a professor, having 18 papers published.
Author contributions: All authors contributed equally to the work.
Supported by the National Natural Science Foundation of China, No.39670344.
Correspondence to: Dr. Jian-Xiang Zhang, Department of Histology and Embryology Hunan Medical University, 88 Xiangya Road, Changsha 410078, China
Telephone: +86-731-4471979 Ext.2880 Fax: +86-731-4471979
Received: November 19, 1998
Revised: December 18, 1998
Accepted: December 30, 1998
Published online: February 15, 1999

AIM To explore the relationship between the rules of Cx gene expression and cellular differ-entiation in organs of different embryonic stages.

METHODS A series of Cx gene serving as molecular probes and the Northern blot hybry-dization were employed to study the Cx gene ex-pression.

RESULTS Cx31, Cx31.1, Cx46 did not express while other Cx genes expressed in the embryon-ic liver and stomach. The Cx gene expression in the liver and stomach showed different state at different embryonic stages. The Cx gene expression had organic diversity. The expression of Cx26 gene was overlapping in the above organs. Cx43 did not express in the human liver after birth, but it expressed in the embryonic stage.

CONCLUSION The expression state of Cx genes is concordant with cellular differentiation. It might be a key candidate gene to regulate some differentiational events associated with cellular differentiation, proliferation, and morphogenesis in the early embryo.

Keywords: liver/embryology, liver/cy-tology, stomach/embryology, stomach/cytology, Cx genes, gene expression