Published online Oct 15, 1998. doi: 10.3748/wjg.v4.i5.430
Revised: June 13, 1998
Accepted: July 21, 1998
Published online: October 15, 1998
AIM: To observe the changes in erythrocyte membrane ATPases and plasma lipid peroxides (LPO) patients with in abdominal surgery under intravenous procaine balanced anesthesia.
METHODS: By determining the ATPase activities of erythrocyte membrane, effects of upper abdominal surgery under intravenous procaine-balanced anesthesia on the function of erythrocytes were observed in 15 patients undergoing cholecystectomy and gastrectomy (5 males and 10 females, aged 45.9 ± 10.20 years and weighed 60.60 kg ± 11.93 kg). All patients were free from severe renal,hepatic, pulmonary, cardiac, metabolic and endocrinological diseases and acute infection for at least 2 weeks before surgery. Patients receiving any drug known to affect carbohydrate metabolism prior to anesthesia were excluded from the study.
RESULTS: Erythrocyte membrane Na+, K+-ATPase, Mg2+-ATPase, Ca2+, Mg2+-ATPase activities were not significantly changed 60 min-90 min after incision as compared with 30min before anesthesia, but were decreased markedly 10min and 24 h after completion of operation (P ＜ 0.01). Plasma lipid peroxides (LPO) were increased significantly 24 h after surgery (P ＜ 0.01) following an initially marked but transient reduction. Plasma LPO changes were not correlated with erythrocyte membrane ATPase activities, r = -0.0396, -0.0097 and 0.4383, respectively (P ＞ 0.05).
CONCLUSION: Abdominal surgical trauma under intravenous procaine-balanced anesthesia may be associated with the decreased ATPase activities of erythrocyte membrane and increased LPO in plasma.