Combined Traditional and Modern Medicine
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jun 15, 1998; 4(3): 260-263
Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.260
Therapeutic effect of Zijin capsule in liver fibrosis in rats
Da-Yong Cai, Gang Zhao, Jia-Chun Chen, Gan-Mei Ye, Fei-Hong Bing, Bu-Wu Fan
Da-Yong Cai, Gang Zhao, Jia-Chun Chen, Gan-Mei Ye, Fei-Hong Bing, Bu-Wu Fan, Department of Basic Medical Sciences, Hubei College of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China
Da-Yong Cai, male, born in 1962 in Hubei Province, graduated from Hubei Medical University as a postgraduate in 1989, now a lecturer of pathology majoring the research of combined TCM and western medicine, having 18 papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Dr. Da-Yong Cai, Department of Basic Medical Sciences, Hubei College of Traditional Chinese Medicine, Wuhan 430061, Hubei Province, China. CZ971010@public.wh.hb.CN
Telephone: +86-27-8863607
Received: February 25, 1998
Revised: April 20, 1998
Accepted: May 12, 1998
Published online: June 15, 1998
Abstract

AIM: To confirm the therapeutic effect of Zijin capsule on liver fibrosis in rat model.

METHODS: Model group: Bovine serum albumin (BSA) Freund’s incomplete adjuvant 0.5 mL was injected subdermally at d1 d15 d22 d29 and d36 for primary sensitization. Seven days after the fifth injection, BSA antibody in the serum was detected by double agar diffusion method. Normal saline of 0.4 mL was injected through cauda vein to BSA antibody-positive rat twice a week for fifteen times. Traditional Chinese medicine (TCM) decoction group and Zijin capsule group: In the attack injection period, Chinese medicinal decoction or Zijin capsule was given ig, the others were the same as in the model group. NS was used in the control group. The collagen content of rat liver was determined by Bergman’s method and expressed as x-±s. The liver pathological changes were divided into four grades and expressed as the avarage of the total rank sum.

RESULTS: The collagen content (mg/g) of the liver in the control group (7.2 ± 1.9) was significantly lower than that in the other groups; it was higher in the model group (31.7 ± 16.6) than that in the two therapeutic groups; and lower in Zijin capsule group (9.7 ± 2.8) than that in the TCM decoction group (11.5 ± 5.3). The pathological changes were more aggravated in the model group (37.4) than those in the two therapeutic groups; and more severe in the TCM decoction group (30.2) than in the Zijin capsule group (22.9).

CONCLUSION: The therapeutic effect of Zijin capsule on the model was confirmed.

Keywords: liver cirrhosis/therapy; Zijin capsule; integrated TCM-WM; diseases models, animal; rats