Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.238
Revised: March 25, 1998
Accepted: May 2, 1998
Published online: June 15, 1998
AIM: To observe the effect of octreotide (OT) and somatostatin (SS) on gallbladder pressure and myoelectric activity of SO in rabbits.
METHODS: Male rabbits fasted for 15 h-18 h and anesthetized with urethane. The mean gallbladder pressure (GP) and myoelectric activity of SO were simutaneously measured with a frog bladder connected to a transducer and a pair of copper electrodes.
RESULTS: After injection of OT (10 μg/kg, iv), the GP decreased in 2 min and reached the lowest value in about 60 min (P < 0.01, n = 19), and completely or partially returned to the normal level in 120 min. The frequency of myoelectric activty of SO was reduced, even disappeared in 2 min (P < 0.01, n = 19) and returned to normal in about 20 min. Injection of SS (10 μg/kg, iv) also decreased GP and myoelectric activity of SO (P < 0.01, n = 7); Before and after injection of OT or SS, injection of CCK-8 (100 ng or 200 ng) caused similar increase in myoelectric activity of SO and GP (P > 0.05). Before and after injection of OT, there were no significant differences in increases of myoelectric activity of SO and GP caused by electric stimulation of dorsal motor nucleus of vagus (P > 0.05).
CONCLUSION: OT and SS decreased GP and myoelectric activity of SO, demonstrating that effects of OT were similar to those of SS. Intravenous injection of OT did not affect the increase of myoelectric activity of SO and GP caused by CCK-8 or electric stimulation of dorsal motor nucleus of vagus.