Original Articles
Copyright ©The Author(s) 1998. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Apr 15, 1998; 4(2): 158-161
Published online Apr 15, 1998. doi: 10.3748/wjg.v4.i2.158
Classification of gastric neuroendocrine tumors and its clinicopathologic significance
Ji-Yao Yu, Lu-Ping Wang, Yu-Hong Meng, Meng Hu, Jia-Ling Wang, C Bordi
Ji-Yao Yu, Yu-Hong Meng, Meng Hu, Jia-Ling Wang, Department of Pathology. Navy General Hospital, Beijing 100037, China
Lu-Ping Wang, The General Hospital of the PLA Beijing Command Area, China
C Bordi, Parma University, Italy
Ji-Yao Yu, male, professor of pathology, having about one hundred papers published.
Author contributions: All authors contributed equally to the work.
Correspondence to: Prof. Ji-Yao Yu, Department of Pathology, Navy General Hospital, Beijing 100037, China
Telephone: +86·10·68587733-58176 Fax: +86·10·68581843
Received: April 17, 1997
Revised: September 20, 1997
Accepted: December 24, 1997
Published online: April 15, 1998

AIMS: To study the pathologic classification of gastric neuroendocrine tumors and its clinicopatho-logic significance.

METHODS: Paraffin-embedded sections of 52 gastric neuroendocrine tumors including 42 carcinoid tumors, and 10 cases of neuroendocrine carcinoma from 326 patients who underwent resection of stomach carcinomas were studied by immunohistochemical methods including 10 endocrine markers or hormones antibodies and endocrine cells in gastric neuroendocrine tumors and extratumoral mucosa were observed under electromicroscope.

RESULTS: The 52 gastric neuroendocrine tumors were divided into three types: ① Gastrin dependent type of carcinoid (26 cases) accompanied by chronic atrophic gastritis (CAG) and tumor extension limited to the mucosa or submucosa complicated with hypergastrinemia and G cell hyperplasia. This type was consistently preceded by and associated with generalized proliferation of endocrine cells in the extratomoral fundic mucosa. ② Non-gastrin dependent type of carcinoids (16 cases) associated with neither CAG nor hypergastrinemia. This type was more aggressive; and ③ Neuroendocrie carcinomas (10 cases), which are highly aggressive tumors.

CONCLUSIONS: A correct identification of different types of gastric endocrine tumors has major implications for the treatment and prognosis of the patients.

Keywords: stomach neoplasms/pathology, neuroendocrine tumors/pathology, carcinoid tumor/pathology, gastritis, atrophic, G cell, immunohistochemistry, microsocopy, electron