Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 14, 2020; 26(46): 7425-7435
Published online Dec 14, 2020. doi: 10.3748/wjg.v26.i46.7425
Infliximab is effective in the treatment of ulcerative colitis with dermatomyositis: A case report
Bin-Bin Huang, Li-Chun Han, Geng-Feng Liu, Xiao-Dan Lv, Guang-Li Gu, Shi-Quan Li, Lan Chen, Hui-Qin Wang, Ling-Ling Zhan, Xiao-Ping Lv
Bin-Bin Huang, Li-Chun Han, Geng-Feng Liu, Guang-Li Gu, Shi-Quan Li, Lan Chen, Hui-Qin Wang, Xiao-Ping Lv, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Xiao-Dan Lv, Ling-Ling Zhan, Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China
Author contributions: Huang BB and Han LC drafted the table and the manuscript; Liu GF and Lv XD searched the relevant literature; Gu GL and Li SQ collected the data; Chen L and Wang HQ contributed to the design and revision of this study; Zhan LL reviewed the literature; Lv XP was the doctor in charge of the patient and revised the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81860104 and 81460114; the Natural Science Foundation of Guangxi Zhuang Autonomous Region, No. 2017GXNSFAA198299; the Development and Application of Medical and Health Appropriate Technology Project in Guangxi Zhuang Autonomous Region, No. S2018049; the Youth Science Foundation of Guangxi Medical University, No. GXMUYSF201913 and GXMUYSF201908; and the Self-financing Project of Health Commission of Guangxi Zhuang Autonomous Region, No. Z20200398.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Xiao-Ping Lv, MM, Chief Physician, Professor, Department of Gastroenterology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lxxp58@hotmail.com
Received: July 28, 2020
Peer-review started: July 28, 2020
First decision: September 30, 2020
Revised: October 11, 2020
Accepted: November 4, 2020
Article in press: November 4, 2020
Published online: December 14, 2020
Abstract
BACKGROUND

Joint, skin, oral cavity, and eye lesions are the most common extraintestinal manifestations of ulcerative colitis that can occur before or after its onset. The cases of ulcerative colitis with dermatomyositis (DM) are rare. In this study, we report a rare case of ulcerative colitis with DM that was effectively treated with infliximab.

CASE SUMMARY

The patient was a 57-year-old female with a 2-year history of DM. The patient was admitted to hospital with abdominal pain, diarrhea, and blood in stool lasting for more than 2 mo. Colonoscopy revealed multiple erosions and ulcers in the entire colon and rectum. Pathological sections showed chronic inflammatory cell infiltration, especially neutrophil infiltration, in the colonic mucosa; therefore, the patient was diagnosed with ulcerative colitis. Preparations of 5-aminosalicylic acid was added to her treatment based on the original treatment for DM, but its effect was unsatisfactory. The patient’s discomfort was relieved after infliximab treatment.

CONCLUSION

Infliximab can improve DM in the treatment of ulcerative colitis. Specialists need to raise awareness about patients with inflammatory bowel disease who have rare extraintestinal manifestations.

Keywords: Ulcerative colitis, Dermatomyositis, Extraintestinal manifestation, Infliximab, Mesalazine, Case report

Core Tip: Few cases of ulcerative colitis have dermatomyositis (DM) as complication. DM may be a less frequent extraintestinal manifestation of ulcerative colitis. Infliximab is effective in the treatment of ulcerative colitis in patients with autoimmune disease or poor hormone response.