Published online Jan 7, 2018. doi: 10.3748/wjg.v24.i1.23
Peer-review started: September 13, 2017
First decision: October 24, 2017
Revised: November 7, 2017
Accepted: November 27, 2017
Article in press: November 27, 2017
Published online: January 7, 2018
To explore the expression profiles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and mRNAs in oesophageal squamous cell carcinoma (ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA (ceRNA) network.
In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.
CeRNAs have the ability to reduce the targeting activity of miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development.
This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers.
Core tip: Competing endogenous RNAs (ceRNAs) may play a critical role in tumourigenesis, and perturbations to ceRNA networks would result in the progression of oesophageal squamous cell carcinoma (ESCC). However, the role of ceRNAs in ESCC has not been comprehensively explored. This study was designed to investigate the expression profiles of microRNAs, long non-coding RNAs, and mRNAs in ESCC to elucidate an oesophageal cancer-specific ceRNA network. Our report reveals potential molecular mechanisms of oesophageal cancer progression and suggests a novel approach to cancer therapeutics in the regulation of ceRNA networks.